Pharmacological properties Pharmacodynamics dihydropyridine derivative – blocker “slow” calcium channels II generation, has antianginal and hypotensive action. Communicating with the dihydropyridine receptor, blocks calcium channels reduces the transmembrane passage of calcium ions into the cell (mainly in vascular smooth muscle cells than cardiac myocytes). Antianginal effect is due to the expansion of the coronary and peripheral arteries and arterioles: angina reduces the severity of myocardial ischemia; expanding peripheral arterioles, decreases total peripheral vascular resistance, decreases the preload on the heart, reducing myocardial oxygen demand. Expanding the major coronary arteries and arterioles in the unaltered and ischemic myocardial areas, increases the ...
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Proviron – tricyclic antidepressant group of non-selective inhibitors of neuronal uptake of monoamines. It possesses strong timoanalepticheskim and sedative effect. pharmacodynamics The mechanism of antidepressant action of proviron is associated with inhibition of reverse neuronal uptake of catecholamines (norepinephrine, dopamine) and serotonin in the central nervous system. proviron is an antagonist of muscarinic cholinergic receptors in the CNS and in the periphery, has a peripheral antihistamine (the HI) and antiadrenergicheskim properties. Also of antinevralgicheskoe (central analgesic), anti-ulcer and antibulimicheskoe action effective for bed-wetting. The antidepressant effect develops within 2-4 weeks. after the start of application. Pharmacokinetics Bioavailability of proviron for ...
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